Endocrine Abstracts

Background: Nocturnal profile of GH secretion is proposed to be a screening diagnostic procedure for GH deficiency (GHD) in short children. Every screening procedure must be characterised by very high sensitivity and good specificity. The data concerning the cut-off level between normal and subnormal nocturnal GH secretion are scarce and non-consistent.The aim of the study was to assess the clinical utility of 2-h nocturnal profile of GH secretion in dia...

Background: Assessment of nocturnal GH secretion is useful tool in diagnosing GH deficiency (GHD) in children. The time period of the evaluation, the number of blood samples, as well as the choice of cut-off value for this examination – are still the matter for discussion.Aim: The aim of the study was to compare the results of 2-h and 6-h assessment of nocturnal GH secretion in children with suspected neurosecretory dysfunction of GH secretion (NSD)...

Introduction: According to a limited number of specialized hospital beds for radioiodine therapy in some countries, fractionated dose of radioiodine may be considered as the ablation therapy of differentiated thyroid cancer (DTC). Aim of the study was to compare the late effects of ablation therapy with single and fractionated dose of radioiodine in patients with DTC.Patients and metods: Patients with DTC treated with one (131)I dose of 2.2 GBq or fracti...

Medical documentation of 976 patients treated and followed-up over the years 2001–2006 at our 131- radioiodine treatment centre was analysed with respect to their thyroid cancer staging. The mean age at their time of diagnosis was 59±15.1 years. From histopathology, papillary, follicular or poorly differentiated cancer was diagnosed in 87.6, 11.7, and 0.7% of these patients, respectively. The mean ages of patients with papillary, follicular or poorly differentiated c...

Adrenal cortex scintigraphy has been used as early as in the 1970s, however, in recent years, it has been a rarely performed and unappreciated examination. In fact, this examination does not provide a perfect view on morphology of adrenal glands, however it provides an assessment of the examined tumor’s function. The aim of this work is to present our experience with adrenal cortex scintigraphy in assessment of adrenal tumors.We present a series of ...

Introduction: Adrenal medullary hyperplasia (AMH) is a rare syndrome of catecholamine excess. Adrenal overgrowth is usually bilateral. Due to similar clinical signs, laboratory results and radiological adrenal picture, AMH can be misdiagnosed as pheochromocytoma. The only method that allows determining a proper diagnosis of AMH is pathologic examination. It is regarded as a precursor of pheochromocytoma and has been reported as a component of MEN2.Aim: T...

Introduction: It has been shown that thyroid cancer has a significant correlation with cancers originated from other organs. The aim of this study was to investigate the association between synchronous primary cancers in patients with thyroid cancer.Material and Method: A retrospective analysis of medical records of 560 thyroid cancer patients treated in the years 2007–2013 and followed up over 2–8 years, was performed. In 38 patients (6.7%), 5...

Introduction: Somatostatin analogues (SSAs) are used in the treatment of somatotropinomas. Actually, the use of these drugs in clinically non-functioning pituitary adenomas (NFPA) is raised. The aim of the study is to assess the effectiveness of SSA therapy in both groups.Materials and methods: 40 acromegalic patients and 22 patients with NFPA were treated with SSA for the total therapy duration up to 10 years. Hormonal profile, dynamics of tumour size c...

The increase in thyroid disease frequency has been observed recently. It may be attributed to the changing iodine status, endocrine disruptors, as well as better availability of ultrasound and laboratory tests. The aim of the study was to assess the occurrence of newly recognized thyroid diseases during long-term follow-up.Material and methods: Study was carried out in 2010–2012 in Krakow area. It included 266 patients aged 23–81 years (168 fem...

Introduction: Hyperparathyroidism during pregnancy is a serious problem. Appropriate management is a matter of debate. We would like to present cases in which, PHP was diagnosed in completely different circumstances, though end up with various pregnancy outcomes.Case report: First patient was 29-year-old women in 21th week of her second pregnancy admitted to our ward due to suspected relapse of Graves’ disease and possible adrenal dysfunction. She p...